Isabelle Bourne scored 21 points and grabbed nine rebounds as No. 22 Nebraska opened the season with a 100-36 win over Omaha.
Allison Weidner added 19 points and nine rebounds, and South Dakota transfer Maddy Krull had 18 points with four 3-pointers for Nebraska.
Alexis Markowski added 13 points and eight rebounds and Jaz Shelley had 10 assists.
Annika Stewart scored 10 points as the Cornhuskers shot over 56%. Elena Pilakouta had 10 points and eight rebounds for the Mavericks, who shot just 21%.
Nineteen turnovers turned into 25 Nebraska points.