Chadron suffered their first loss of the season on homecoming night as Mitchell beat the Cardinals 35-14.
The Tigers scored just two minutes into the game on a run of over 70-yards, and then tacked on another touchdown from just a yard out to grab a 14-0 lead.
Xander Provance grabbed a Justus Alcorn pass to cut the deficit in half after the 1st quarter.
The teams would trade touchdowns in the 2nd quarter to give Mitchell the 21-14 halftime lead.
The Cardinals went three and out to start the 2nd half and Mitchell took over from there adding a pair of scores to reach the final tally.
Chadron, now 3-1, will try to rebound next Friday at Sidney.