Morgan Maly matched her career-high with 21 points and had 10 rebounds for her second career double-double and No. 21 Creighton completed a sweep of the Mount Rushmore state with a 74-51 win over South Dakota.
The Bluejays, who opened the season with a win at No. 23 South Dakota State, got 16 points from Molly Mogensen.
South Dakota led 19-12 after one quarter, but the Bluejays dominated the second 21-3 to lead 33-22 at the half.
Grace Larkins scored 20 points for the Coyotes.